Structure Based Design of Bicyclic Peptide Inhibitors of RbAp48

The scaffolding protein RbAp48 is part of several epigenetic regulation complexes and is overexpressed in a variety of cancers. In order to develop tool compounds for the study of RbAp48 function, we have developed peptide inhibitors targeting the protein–protein interaction interface between RbAp48...

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Veröffentlicht in:Angew Chem Int Ed Engl
Hauptverfasser: Hart, Peter 't, Hommen, Pascal, Noisier, Anaïs, Krzyzanowski, Adrian, Schüler, Darijan, Porfetye, Arthur T., Akbarzadeh, Mohammad, Vetter, Ingrid R., Adihou, Hélène, Waldmann, Herbert
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7894522/
https://ncbi.nlm.nih.gov/pubmed/33022847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202009749
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