Model‐Informed Pediatric Dose Selection for Dapagliflozin by Incorporating Developmental Changes

This analysis reports a quantitative modeling and simulation approach for oral dapagliflozin, a primarily uridine diphosphate‐glucuronosyltransferase (UGT)–metabolized human sodium‐glucose cotransporter 2 selective inhibitor. A mechanistic dapagliflozin physiologically based pharmacokinetic (PBPK) m...

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Enregistré dans:
Détails bibliographiques
Publié dans:CPT Pharmacometrics Syst Pharmacol
Auteurs principaux: Jo, Heeseung, Pilla Reddy, Venkatesh, Parkinson, Joanna, Boulton, David W., Tang, Weifeng
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2021
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7894404/
https://ncbi.nlm.nih.gov/pubmed/33439535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12577
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