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Ribociclib enhances infigratinib‐induced cancer cell differentiation and delays resistance in FGFR‐driven hepatocellular carcinoma

BACKGROUND & AIMS: Infigratinib is a pan‐FGFR (fibroblast growth factor receptor) inhibitor that has shown encouraging activity in FGFR‐dependent hepatocellular carcinoma (HCC) models. However, long‐term treatment results in the emergence of resistant colonies. We sought to understand the mechan...

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Publicado en:Liver Int
Autores principales: Prawira, Aldo, Le, Thi Bich Uyen, Vu, Thanh Chung, Huynh, Hung
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7894323/
https://ncbi.nlm.nih.gov/pubmed/33179425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/liv.14728
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