Infigratinib Mediates Vascular Normalization, Impairs Metastasis, and Improves Chemotherapy in Hepatocellular Carcinoma

The fibroblast growth factor (FGF) signaling cascade is a key signaling pathway in hepatocarcinogenesis. We report high FGF receptor (FGFR) expression in 17.7% (11 of 62) of hepatocellular carcinoma (HCC) models. Infigratinib, a pan‐FGFR inhibitor, potently suppresses the growth of high‐FGFR‐express...

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Bibliografiske detaljer
Udgivet i:Hepatology
Main Authors: Huynh, Hung, Lee, Liek Yeow, Goh, Kah Yong, Ong, Richard, Hao, Huai‐Xiang, Huang, Alan, Wang, Youzhen, Graus Porta, Diana, Chow, Pierce, Chung, Alexander
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Rapid Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6635738/
https://ncbi.nlm.nih.gov/pubmed/30575985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30481
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