Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR

SHP2 mediates RAS activation downstream of multiple receptor tyrosine kinases (RTKs) and cancer cell lines dependent on RTKs are in general dependent on SHP2. Profiling of the allosteric SHP2 inhibitor SHP099 across cancer cell lines harboring various RTK dependencies reveals that FGFR-dependent cel...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Lu, Hengyu, Liu, Chen, Huynh, Hung, Le, Thi Bich Uyen, LaMarche, Matthew J., Mohseni, Morvarid, Engelman, Jeffrey A., Hammerman, Peter S., Caponigro, Giordano, Hao, Huai-Xiang
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980623/
https://ncbi.nlm.nih.gov/pubmed/32076487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27435
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