A conserved PI(4,5)P2–binding domain is critical for immune regulatory function of DOCK8

DOCK8 is a Cdc42-specific guanine-nucleotide exchange factor that is essential for development and functions of various subsets of leukocytes in innate and acquired immune responses. Although DOCK8 plays a critical role in spatial control of Cdc42 activity during interstitial leukocyte migration, th...

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Bibliographic Details
Published in:Life Sci Alliance
Main Authors: Sakurai, Tetsuya, Kukimoto-Niino, Mutsuko, Kunimura, Kazufumi, Yamane, Nana, Sakata, Daiji, Aihara, Ryosuke, Yasuda, Tomoharu, Yokoyama, Shigeyuki, Shirouzu, Mikako, Fukui, Yoshinori, Uruno, Takehito
Format: Artigo
Language:Inglês
Published: Life Science Alliance LLC 2021
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7893821/
https://ncbi.nlm.nih.gov/pubmed/33574036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.202000873
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