27-Hydroxycholesterol induces macrophage gene expression via LXR-dependent and -independent mechanisms

27-Hydroxycholesterol (27OHChol) exhibits agonistic activity for liver X receptors (LXRs). To determine roles of the LXR agonistic activity in macrophage gene expression, we investigated the effects of LXR inhibition on the 27OHChol-induced genes. Treatment of human THP-1 cells with GSK 2033, a pote...

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Vydáno v:Korean J Physiol Pharmacol
Hlavní autoři: Kim, Bo-Young, Son, Yonghae, Cho, Hyok-rae, Lee, Dongjun, Eo, Seong-Kug, Kim, Koanhoi
Médium: Artigo
Jazyk:Inglês
Vydáno: The Korean Physiological Society and The Korean Society of Pharmacology 2021
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7893494/
https://ncbi.nlm.nih.gov/pubmed/33602881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4196/kjpp.2021.25.2.111
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