Multiscale Modeling of Germinal Center Recapitulates the Temporal Transition From Memory B Cells to Plasma Cells Differentiation as Regulated by Antigen Affinity-Based Tfh Cell Help

Germinal centers play a key role in the adaptive immune system since they are able to produce memory B cells and plasma cells that produce high affinity antibodies for an effective immune protection. The mechanisms underlying cell-fate decisions are not well understood but asymmetric division of ant...

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Dettagli Bibliografici
Pubblicato in:Front Immunol
Autori principali: Merino Tejero, Elena, Lashgari, Danial, García-Valiente, Rodrigo, Gao, Xuefeng, Crauste, Fabien, Robert, Philippe A., Meyer-Hermann, Michael, Martínez, María Rodríguez, van Ham, S. Marieke, Guikema, Jeroen E. J., Hoefsloot, Huub, van Kampen, Antoine H. C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7892951/
https://ncbi.nlm.nih.gov/pubmed/33613551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.620716
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