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PANDAA intentionally violates conventional qPCR design to enable durable, mismatch-agnostic detection of highly polymorphic pathogens

Sensitive and reproducible diagnostics are fundamental to containing the spread of existing and emerging pathogens. Despite the reliance of clinical virology on qPCR, technical challenges persist that compromise their reliability for sustainable epidemic containment as sequence instability in probe-...

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Détails bibliographiques
Publié dans:Commun Biol
Auteurs principaux: MacLeod, Iain J., Rowley, Christopher F., Essex, M.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7892852/
https://ncbi.nlm.nih.gov/pubmed/33603155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01751-9
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