Genome-wide association of phenotypes based on clustering patterns of hand osteoarthritis identify WNT9A as novel osteoarthritis gene

BACKGROUND: Despite recent advances in the understanding of the genetic architecture of osteoarthritis (OA), only two genetic loci have been identified for OA of the hand, in part explained by the complexity of the different hand joints and heterogeneity of OA pathology. METHODS: We used data from t...

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Détails bibliographiques
Publié dans:Ann Rheum Dis
Auteurs principaux: Boer, Cindy Germaine, Yau, Michelle S, Rice, Sarah J, Coutinho de Almeida, Rodrigo, Cheung, Kathleen, Styrkarsdottir, Unnur, Southam, Lorraine, Broer, Linda, Wilkinson, Jeremy Mark, Uitterlinden, André G, Zeggini, Eleftheria, Felson, David, Loughlin, John, Young, Mariel, Capellini, Terence Dante, Meulenbelt, Ingrid, van Meurs, Joyce BJ
Format: Artigo
Langue:Inglês
Publié: BMJ Publishing Group 2021
Sujets:
Osteoarthritis
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7892373/
https://ncbi.nlm.nih.gov/pubmed/33055079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2020-217834
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