Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis

Osteoarthritis is a common complex disease with huge public health burden. Here we perform a genome-wide association study for osteoarthritis using data across 16.5 million variants from the UK Biobank resource. Following replication and meta-analysis in up to 30,727 cases and 297,191 controls, we r...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Zengini, Eleni, Hatzikotoulas, Konstantinos, Tachmazidou, Ioanna, Steinberg, Julia, Hartwig, Fernando P., Southam, Lorraine, Hackinger, Sophie, Boer, Cindy G., Styrkarsdottir, Unnur, Gilly, Arthur, Suveges, Daniel, Killian, Britt, Ingvarsson, Thorvaldur, Jonsson, Helgi, Babis, George C., McCaskie, Andrew, Uitterlinden, Andre G., van Meurs, Joyce B. J., Thorsteinsdottir, Unnur, Stefansson, Kari, Smith, George Davey, Wilkinson, Jeremy M., Zeggini, Eleftheria
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896734/
https://ncbi.nlm.nih.gov/pubmed/29559693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0079-y
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