Evaluation of shared genetic aetiology between osteoarthritis and bone mineral density identifies SMAD3 as a novel osteoarthritis risk locus

Osteoarthritis (OA) is a common complex disease with high public health burden and no curative therapy. High bone mineral density (BMD) is associated with an increased risk of developing OA, suggesting a shared underlying biology. Here, we performed the first systematic overlap analysis of OA and BM...

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Publicado en:Hum Mol Genet
Autores principales: Hackinger, Sophie, Trajanoska, Katerina, Styrkarsdottir, Unnur, Zengini, Eleni, Steinberg, Julia, Ritchie, Graham R.S., Hatzikotoulas, Konstantinos, Gilly, Arthur, Evangelou, Evangelos, Kemp, John P., Evans, David, Ingvarsson, Thorvaldur, Jonsson, Helgi, Thorsteinsdottir, Unnur, Stefansson, Kari, McCaskie, Andrew W., Brooks, Roger A., Wilkinson, Jeremy M., Rivadeneira, Fernando, Zeggini, Eleftheria
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2017
Materias:
Association Studies Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886098/
https://ncbi.nlm.nih.gov/pubmed/28934396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx285
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