Evaluation of shared genetic aetiology between osteoarthritis and bone mineral density identifies SMAD3 as a novel osteoarthritis risk locus

Osteoarthritis (OA) is a common complex disease with high public health burden and no curative therapy. High bone mineral density (BMD) is associated with an increased risk of developing OA, suggesting a shared underlying biology. Here, we performed the first systematic overlap analysis of OA and BM...

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Bibliographic Details
Published in:Hum Mol Genet
Main Authors: Hackinger, Sophie, Trajanoska, Katerina, Styrkarsdottir, Unnur, Zengini, Eleni, Steinberg, Julia, Ritchie, Graham R.S., Hatzikotoulas, Konstantinos, Gilly, Arthur, Evangelou, Evangelos, Kemp, John P., Evans, David, Ingvarsson, Thorvaldur, Jonsson, Helgi, Thorsteinsdottir, Unnur, Stefansson, Kari, McCaskie, Andrew W., Brooks, Roger A., Wilkinson, Jeremy M., Rivadeneira, Fernando, Zeggini, Eleftheria
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
Subjects:
Association Studies Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886098/
https://ncbi.nlm.nih.gov/pubmed/28934396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx285
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