Staphylococcus aureus resistance to albocycline can be achieved by mutations that alter cellular NAD/PH pools

Small molecule target identification is a critical step in modern antibacterial drug discovery, particularly against multi-drug resistant pathogens. Albocycline (ALB) is a macrolactone natural product with potent activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resi...

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Publicat a:Bioorg Med Chem
Autors principals: Scherzi, Tyler, D’Ambrosio, Elizabeth A., Daher, Samer S., Grimes, Catherine L., Dunman, Paul M., Andrade, Rodrigo B.
Format: Artigo
Idioma:Inglês
Publicat: 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7891091/
https://ncbi.nlm.nih.gov/pubmed/33477021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2021.115995
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