Overexpression of HIPK2 removes the transrepression of proapoptotic genes mediated by the CtBP1-p300-FOXO3a complex and increases the chemosensitivity in osteosarcoma cells

Decreased expression of proapoptotic genes can lead to the chemoresistenance in cancer therapy. Carboxyl-terminal binding protein 1 (CtBP1), a transcriptional corepressor with multiple oncogenic effects, has been previously identified to suppress the expression of two proapoptotic genes [BAX (BCL2 a...

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Detalhes bibliográficos
Publicado no:J Cancer
Main Authors: Duan, Ning, Zhang, Wentao, Li, Zhong, Sun, Liang, Song, Tao, Yu, Zirui, Chen, Xun, Ma, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2021
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7890331/
https://ncbi.nlm.nih.gov/pubmed/33613771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.52115
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