Targeting the CtBP1-FOXM1 transcriptional complex with small molecules to overcome MDR1-mediated chemoresistance in osteosarcoma cancer stem cells

Chemoresistance is a major barrier for the chemotherapy of osteosarcoma. The induction of multidrug resistance protein 1 (MDR1), an ATP-dependent transporter, can efflux anti-cancer drugs, thereby decreasing chemosensitivity. However, an actual involvement of MDR1 in the chemoresistance of osteosarc...

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Vydáno v:J Cancer
Hlavní autoři: Chen, Xun, Zhang, Qian, Dang, Xiaoqian, Song, Tao, Wang, Yufei, Yu, Zirui, Zhang, Shihui, Fan, Jinzhu, Cong, Fei, Zhang, Wentao, Duan, Ning
Médium: Artigo
Jazyk:Inglês
Vydáno: Ivyspring International Publisher 2021
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7739006/
https://ncbi.nlm.nih.gov/pubmed/33391445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.50255
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