Impaired NEPHRIN localization in kidney organoids derived from nephrotic patient iPS cells

Mutations in the NPHS1 gene, which encodes NEPHRIN, cause congenital nephrotic syndrome, resulting from impaired slit diaphragm (SD) formation in glomerular podocytes. We previously reported NEPHRIN and SD abnormalities in the podocytes of kidney organoids generated from patient-derived induced plur...

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Publicat a:Sci Rep
Autors principals: Ohmori, Tomoko, De, Shankhajit, Tanigawa, Shunsuke, Miike, Koichiro, Islam, Mazharul, Soga, Minami, Era, Takumi, Shiona, Shinichi, Nakanishi, Koichi, Nakazato, Hitoshi, Nishinakamura, Ryuichi
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7890052/
https://ncbi.nlm.nih.gov/pubmed/33597637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-83501-9
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