Organoids from Nephrotic Disease-Derived iPSCs Identify Impaired NEPHRIN Localization and Slit Diaphragm Formation in Kidney Podocytes

Mutations in the NPHS1 gene, which encodes NEPHRIN, cause congenital nephrotic syndrome, resulting from impaired slit diaphragm (SD) formation in glomerular podocytes. However, methods for SD reconstitution have been unavailable, thereby limiting studies in the field. In the present study, we establ...

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Publicat a:Stem Cell Reports
Autors principals: Tanigawa, Shunsuke, Islam, Mazharul, Sharmin, Sazia, Naganuma, Hidekazu, Yoshimura, Yasuhiro, Haque, Fahim, Era, Takumi, Nakazato, Hitoshi, Nakanishi, Koichi, Sakuma, Tetsushi, Yamamoto, Takashi, Kurihara, Hidetake, Taguchi, Atsuhiro, Nishinakamura, Ryuichi
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6135868/
https://ncbi.nlm.nih.gov/pubmed/30174315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.08.003
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