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High-throughput screening of histone deacetylases and determination of kinetic parameters using fluorogenic assays

Histone deacetylases (HDACs) are ubiquitous enzymes that cleave post-translational ε-N-acyllysine modifications. The continued identification of diverse acyl modifications at lysine residues in proteins has resulted in discovery of new insight into the biological roles of these enzymes. Here, we des...

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Dettagli Bibliografici
Pubblicato in:STAR Protoc
Autori principali: Moreno-Yruela, Carlos, Olsen, Christian A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7890041/
https://ncbi.nlm.nih.gov/pubmed/33659897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xpro.2021.100313
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