Microfluidic tumor-on-a-chip model to evaluate the role of tumor environmental stress on NK cell exhaustion

Solid tumors generate a suppressive environment that imposes an overwhelming burden on the immune system. Nutrient depletion, waste product accumulation, hypoxia, and pH acidification severely compromise the capacity of effector immune cells such as T and natural killer (NK) cells to destroy cancer...

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Bibliografiske detaljer
Udgivet i:Sci Adv
Main Authors: Ayuso, Jose M., Rehman, Shujah, Virumbrales-Munoz, Maria, McMinn, Patrick H., Geiger, Peter, Fitzgerald, Cate, Heaster, Tiffany, Skala, Melissa C., Beebe, David J.
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2021
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7888951/
https://ncbi.nlm.nih.gov/pubmed/33597234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc2331
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