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Microfluidic tumor-on-a-chip model to evaluate the role of tumor environmental stress on NK cell exhaustion
Solid tumors generate a suppressive environment that imposes an overwhelming burden on the immune system. Nutrient depletion, waste product accumulation, hypoxia, and pH acidification severely compromise the capacity of effector immune cells such as T and natural killer (NK) cells to destroy cancer...
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| Publicado en: | Sci Adv |
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| Autores principales: | , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Association for the Advancement of Science
2021
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7888951/ https://ncbi.nlm.nih.gov/pubmed/33597234 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc2331 |
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