The E3 ubiquitin ligase Cul4b promotes CD4(+) T cell expansion by aiding the repair of damaged DNA

The capacity for T cells to become activated and clonally expand during pathogen invasion is pivotal for protective immunity. Our understanding of how T cell receptor (TCR) signaling prepares cells for this rapid expansion remains limited. Here we provide evidence that the E3 ubiquitin ligase Cullin...

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Publicado en:PLoS Biol
Main Authors: Dar, Asif A., Sawada, Keisuke, Dybas, Joseph M., Moser, Emily K., Lewis, Emma L., Park, Eddie, Fazelinia, Hossein, Spruce, Lynn A., Ding, Hua, Seeholzer, Steven H., Oliver, Paula M.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2021
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7888682/
https://ncbi.nlm.nih.gov/pubmed/33524014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3001041
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