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The E3 ubiquitin ligase Itch restricts antigen-driven B cell responses
The E3 ubiquitin ligase Itch regulates antibody levels and prevents autoimmune disease in humans and mice, yet how Itch regulates B cell fate or function is unknown. We now show that Itch directly limits B cell activity. While Itch-deficient mice displayed normal numbers of preimmune B cell populati...
Tallennettuna:
| Julkaisussa: | J Exp Med |
|---|---|
| Päätekijät: | , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Rockefeller University Press
2019
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6719427/ https://ncbi.nlm.nih.gov/pubmed/31311822 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20181953 |
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