Environment-Sensitive Polymeric Micelles Encapsulating SN-38 Potently Suppress Growth of Neuroblastoma Cells Exhibiting Intrinsic and Acquired Drug Resistance

[Image: see text] Conventional treatment approaches fail to provide durable control over aggressive malignancies due to intrinsic or acquired drug resistance characteristic of high-risk disease. SN-38, a potent camptothecin analog specifically targeting DNA topoisomerase I cleavage complexes, has sh...

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Bibliografske podrobnosti
izdano v:ACS Pharmacol Transl Sci
Main Authors: Polunin, Yehor, Alferiev, Ivan S., Brodeur, Garrett M., Voronov, Andriy, Chorny, Michael
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2020
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7887841/
https://ncbi.nlm.nih.gov/pubmed/33615176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.0c00182
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