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Nanoparticle Delivery of an SN38 Conjugate is More Effective Than Irinotecan in a Mouse Model of Neuroblastoma

Neuroblastoma (NB) is the most common and deadly solid tumor in children. The majority of NB patients have advanced stage disease with poor prognosis, so more effective, less toxic therapy is needed. We developed a novel nanocarrier-based strategy for tumor-targeted delivery of a prodrug of SN38, th...

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Detalhes bibliográficos
Publicado no:Cancer Lett
Main Authors: Iyer, Radhika, Croucher, Jamie L., Chorny, Michael, Mangino, Jennifer L., Alferiev, Ivan S., Levy, Robert J., Kolla, Venkatadri, Brodeur, Garrett M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361245/
https://ncbi.nlm.nih.gov/pubmed/25684664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2015.02.011
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