Polyfunctional Tier 2–Neutralizing Antibodies Cloned following HIV-1 Env Macaque Immunization Mirror Native Antibodies in a Human Donor

Vaccine efforts to combat HIV are challenged by the global diversity of viral strains and shielding of neutralization epitopes on the viral envelope glycoprotein trimer. Even so, the isolation of broadly neutralizing Abs from infected individuals suggests the potential for eliciting protective Abs t...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Spencer, David A., Malherbe, Delphine C., Vázquez Bernat, Néstor, Ádori, Monika, Goldberg, Benjamin, Dambrauskas, Nicholas, Henderson, Heidi, Pandey, Shilpi, Cheever, Tracy, Barnette, Philip, Sutton, William F., Ackerman, Margaret E., Kobie, James J., Sather, D. Noah, Karlsson Hedestam, Gunilla B., Haigwood, Nancy L., Hessell, Ann J.
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2021
Assuntos:
Immunotherapy and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7887735/
https://ncbi.nlm.nih.gov/pubmed/33472907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2001082
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