Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum

The most advanced P. falciparum circumsporozoite protein-based malaria vaccine, RTS,S/AS01 (RTS,S), confers partial protection but with antibody titers that wane relatively rapidly, highlighting the need to elicit more potent and durable antibody responses. Here, we elucidate crystal structures, bin...

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Pubblicato in:Nat Commun
Autori principali: Pholcharee, Tossapol, Oyen, David, Flores-Garcia, Yevel, Gonzalez-Paez, Gonzalo, Han, Zhen, Williams, Katherine L., Volkmuth, Wayne, Emerling, Daniel, Locke, Emily, Richter King, C., Zavala, Fidel, Wilson, Ian A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7887213/
https://ncbi.nlm.nih.gov/pubmed/33594061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21221-4
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