Kappa opioid receptor activation in the amygdala disinhibits CRF neurons to generate pain-like behaviors.

Recent evidence suggests that kappa opioid receptors (KOR) in limbic brain regions such as the amygdala contribute to pain conditions, but underlying mechanisms remain to be determined. The amygdala is an important player in averse-affective aspects of pain and pain modulation. The central nucleus (...

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Bibliographic Details
Published in:Neuropharmacology
Main Authors: Hein, Matthew, Ji, Guangchen, Tidwell, Dalton, D’Souza, Preston, Kiritoshi, Takaki, Yakhnitsa, Vadim, Navratilova, Edita, Porreca, Frank, Neugebauer, Volker
Format: Artigo
Language:Inglês
Published: 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7887082/
https://ncbi.nlm.nih.gov/pubmed/33444637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2021.108456
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