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Kappa opioid signaling in the central nucleus of the amygdala promotes disinhibition and aversiveness of chronic neuropathic pain

Chronic pain is associated with neuroplastic changes in the amygdala that may promote hyper-responsiveness to mechanical and thermal stimuli (allodynia and hyperalgesia) and/or enhance emotional and affective consequences of pain. Stress promotes dynorphin-mediated signaling at the kappa opioid rece...

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Detalhes bibliográficos
Publicado no:Pain
Main Authors: Navratilova, Edita, Ji, Guangchen, Phelps, Caroline, Qu, Chaoling, Hein, Matthew, Yakhnitsa, Vadim, Neugebauer, Volker, Porreca, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6424634/
https://ncbi.nlm.nih.gov/pubmed/30681985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000001458
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