Kappa opioid receptor activation in the amygdala disinhibits CRF neurons to generate pain-like behaviors.

Recent evidence suggests that kappa opioid receptors (KOR) in limbic brain regions such as the amygdala contribute to pain conditions, but underlying mechanisms remain to be determined. The amygdala is an important player in averse-affective aspects of pain and pain modulation. The central nucleus (...

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Publicado en:Neuropharmacology
Main Authors: Hein, Matthew, Ji, Guangchen, Tidwell, Dalton, D’Souza, Preston, Kiritoshi, Takaki, Yakhnitsa, Vadim, Navratilova, Edita, Porreca, Frank, Neugebauer, Volker
Formato: Artigo
Idioma:Inglês
Publicado: 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7887082/
https://ncbi.nlm.nih.gov/pubmed/33444637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2021.108456
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