Dexmedetomidine and clonidine attenuate sevoflurane-induced Tau phosphorylation and cognitive impairment in young mice via alpha-2 adrenergic receptor

BACKGROUND: Anesthetic sevoflurane induces Tau phosphorylation and cognitive impairment in young mice. The underlying mechanism and the targeted interventions remain largely unexplored. We hypothesized that dexmedetomidine and clonidine attenuated sevoflurane-induced Tau phosphorylation and cognitiv...

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Detalhes bibliográficos
Publicado no:Anesth Analg
Main Authors: Sun, Mingyang, Dong, Yuanlin, Li, Mengzhu, Zhang, Yiying, Liang, Feng, Zhang, Jiaqiang, Soriano, Sulpicio G., Xie, Zhongcong
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7887006/
https://ncbi.nlm.nih.gov/pubmed/33181559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ANE.0000000000005268
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