Tau contributes to sevoflurane-induced neurocognitive impairment in neonatal mice

BACKGROUND: Sevoflurane anesthesia induces Tau phosphorylation and cognitive impairment in neonatal but not in adult mice. Here we tested the hypothesis that differences in brain Tau amounts and in the activity of mitochondria-ATP-Nuak1-Tau cascade between the neonatal and adult mice contribute to t...

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Publicado en:Anesthesiology
Autores principales: Yu, Yang, Yang, Yongyan, Tan, Hong, Boukhali, Myriam, Khatri, Ashok, Yu, Yonghao, Hua, Fuzhou, Liu, Ling, Li, Mengzhu, Yang, Guang, Dong, Yuanlin, Zhang, Yiying, Haas, Wilhelm, Xie, Zhongcong
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429299/
https://ncbi.nlm.nih.gov/pubmed/32701572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000003452
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