The anesthetic sevoflurane induces tau trafficking from neurons to microglia

Accumulation and spread of tau in Alzheimer’s disease and other tauopathies occur in a prion-like manner. However, the mechanisms and downstream consequences of tau trafficking remain largely unknown. We hypothesized that tau traffics from neurons to microglia via extracellular vesicles (EVs), leadi...

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Gepubliceerd in:Commun Biol
Hoofdauteurs: Dong, Yuanlin, Liang, Feng, Huang, Lining, Fang, Fang, Yang, Guang, Tanzi, Rudolph E., Zhang, Yiying, Quan, Qimin, Xie, Zhongcong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8115254/
https://ncbi.nlm.nih.gov/pubmed/33980987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-02047-8
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