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Molecular communication of the membrane insertase YidC with translocase SecYEG affects client proteins

The membrane insertase YidC inserts newly synthesized proteins by its hydrophobic slide consisting of the two transmembrane (TM) segments TM3 and TM5. Mutations in this part of the protein affect the insertion of the client proteins. We show here that a quintuple mutation, termed YidC-5S, inhibits t...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Steudle, Anja, Spann, Dirk, Pross, Eva, Shanmugam, Sri Karthika, Dalbey, Ross E., Kuhn, Andreas
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2021
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7886851/
https://ncbi.nlm.nih.gov/pubmed/33594158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-83224-x
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