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Phospho-Form Specific Substrates of Protein Kinase B (AKT1)

Protein kinase B (AKT1) is hyper-activated in diverse human tumors. AKT1 is activated by phosphorylation at two key regulatory sites, Thr308 and Ser473. Active AKT1 phosphorylates many, perhaps hundreds, of downstream cellular targets in the cytosol and nucleus. AKT1 is well-known for phosphorylatin...

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Библиографические подробности
Опубликовано в: :Front Bioeng Biotechnol
Главные авторы: McKenna, McShane, Balasuriya, Nileeka, Zhong, Shanshan, Li, Shawn Shun-Cheng, O'Donoghue, Patrick
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2021
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7886700/
https://ncbi.nlm.nih.gov/pubmed/33614606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2020.619252
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