Phosphorylation-dependent substrate selectivity of protein kinase B (AKT1)

Protein kinase B (AKT1) is a central node in a signaling pathway that regulates cell survival. The diverse pathways regulated by AKT1 are communicated in the cell via the phosphorylation of perhaps more than 100 cellular substrates. AKT1 is itself activated by phosphorylation at Thr-308 and Ser-473....

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Publicado no:J Biol Chem
Main Authors: Balasuriya, Nileeka, Davey, Norman E., Johnson, Jared L., Liu, Huadong, Biggar, Kyle K., Cantley, Lewis C., Li, Shawn Shun-Cheng, O'Donoghue, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294097/
https://ncbi.nlm.nih.gov/pubmed/32350110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.012425
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