Characterization and Validation of Arg286 Residue of IL-1RAcP as a Potential Drug Target for Osteoarthritis

Osteoarthritis (OA) is the most common form of arthritis and the fastest growing cause of chronic disability in the world. Formation of the ternary IL-1β /IL-1R1/IL-1RAcP protein complex and its downstream signaling has been implicated in osteoarthritis pathology. Current OA therapeutic approaches t...

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Detalhes bibliográficos
Publicado no:Front Chem
Main Authors: Dailing, Angela, Mitchell, Kelsey, Vuong, Ngoc, Lee, Kyung Hyeon, Joshi, Reva, Espina, Virginia, Haymond Still, Amanda, Gottschalk, Carter J., Brown, Anne M., Paige, Mikell, Liotta, Lance A., Luchini, Alessandra
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7886681/
https://ncbi.nlm.nih.gov/pubmed/33614593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.601477
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