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Protein painting reveals solvent-excluded drug targets hidden within native protein–protein interfaces

Identifying the contact regions between a protein and its binding partners is essential for creating therapies that block the interaction. Unfortunately, such contact regions are extremely difficult to characterize because they are hidden inside the binding interface. Here we introduce protein paint...

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Bibliografski detalji
Glavni autori: Luchini, Alessandra, Espina, Virginia, Liotta, Lance A.
Format: Artigo
Jezik:Inglês
Izdano: Nature Pub. Group 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109009/
https://ncbi.nlm.nih.gov/pubmed/25048602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5413
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