p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR)

The most common genetic cause of ALS and FTD is a GGGGCC repeat expansion in the C9orf72 gene. We developed a platform to interrogate the chromatin accessibility landscape and transcriptional program within neurons during degeneration. We provide evidence that neurons expressing the dipeptide repeat...

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Pubblicato in:Cell
Autori principali: Maor-Nof, Maya, Shipony, Zohar, Lopez-Gonzalez, Rodrigo, Nakayama, Lisa, Zhang, Yong-Jie, Couthouis, Julien, Blum, Jacob A., Castruita, Patricia A., Linares, Gabriel R., Ruan, Kai, Ramaswami, Gokul, Simon, David J., Nof, Aviv, Santana, Manuel, Han, Kyuho, Sinnott-Armstrong, Nasa, Bassik, Michael C., Geschwind, Daniel H., Tessier-Lavigne, Marc, Attardi, Laura D., Lloyd, Thomas E., Ichida, Justin K., Gao, Fen-Biao, Greenleaf, William J., Yokoyama, Jennifer S., Petrucelli, Leonard, Gitler, Aaron D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7886018/
https://ncbi.nlm.nih.gov/pubmed/33482083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.12.025
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