The role of pro-opiomelanocortin in the ACTH–cortisol dissociation of sepsis

BACKGROUND: Sepsis is typically hallmarked by high plasma (free) cortisol and suppressed cortisol breakdown, while plasma adrenocorticotropic hormone (ACTH) is not increased, referred to as ‘ACTH–cortisol dissociation.’ We hypothesized that sepsis acutely activates the hypothalamus to generate, via...

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Bibliografiske detaljer
Udgivet i:Crit Care
Main Authors: Téblick, Arno, Vander Perre, Sarah, Pauwels, Lies, Derde, Sarah, Van Oudenhove, Tim, Langouche, Lies, Van den Berghe, Greet
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7885358/
https://ncbi.nlm.nih.gov/pubmed/33593393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13054-021-03475-y
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