ACTH and cortisol responses to CRH in acute, subacute, and prolonged critical illness: a randomized, double-blind, placebo-controlled, crossover cohort study

PURPOSE: Low plasma ACTH in critically ill patients may be explained by shock/inflammation-induced hypothalamus-pituitary damage or by feedback inhibition exerted by elevated plasma free cortisol. One can expect augmented/prolonged ACTH-responses to CRH injection with hypothalamic damage, immediatel...

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Bibliografiska uppgifter
I publikationen:Intensive Care Med
Huvudupphovsmän: Peeters, Bram, Meersseman, Philippe, Vander Perre, Sarah, Wouters, Pieter J., Debaveye, Yves, Langouche, Lies, Van den Berghe, Greet
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer Berlin Heidelberg 2018
Ämnen:
Original
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6280831/
https://ncbi.nlm.nih.gov/pubmed/30374692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00134-018-5427-y
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