STIM2 Mediates Excessive Store-Operated Calcium Entry in Patient-Specific iPSC-Derived Neurons Modeling a Juvenile Form of Huntington's Disease

Huntington's disease (HD) is a severe autosomal-dominant neurodegenerative disorder caused by a mutation within a gene, encoding huntingtin protein. Here we have used the induced pluripotent stem cell technology to produce patient-specific terminally differentiated GABA-ergic medium spiny neuro...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Vigont, Vladimir A., Grekhnev, Dmitriy A., Lebedeva, Olga S., Gusev, Konstantin O., Volovikov, Egor A., Skopin, Anton Yu., Bogomazova, Alexandra N., Shuvalova, Lilia D., Zubkova, Olga A., Khomyakova, Ekaterina A., Glushankova, Lyubov N., Klyushnikov, Sergey A., Illarioshkin, Sergey N., Lagarkova, Maria A., Kaznacheyeva, Elena V.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7884642/
https://ncbi.nlm.nih.gov/pubmed/33604336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.625231
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