STIM2 Mediates Excessive Store-Operated Calcium Entry in Patient-Specific iPSC-Derived Neurons Modeling a Juvenile Form of Huntington's Disease

Huntington's disease (HD) is a severe autosomal-dominant neurodegenerative disorder caused by a mutation within a gene, encoding huntingtin protein. Here we have used the induced pluripotent stem cell technology to produce patient-specific terminally differentiated GABA-ergic medium spiny neuro...

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Dettagli Bibliografici
Pubblicato in:Front Cell Dev Biol
Autori principali: Vigont, Vladimir A., Grekhnev, Dmitriy A., Lebedeva, Olga S., Gusev, Konstantin O., Volovikov, Egor A., Skopin, Anton Yu., Bogomazova, Alexandra N., Shuvalova, Lilia D., Zubkova, Olga A., Khomyakova, Ekaterina A., Glushankova, Lyubov N., Klyushnikov, Sergey A., Illarioshkin, Sergey N., Lagarkova, Maria A., Kaznacheyeva, Elena V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Cell and Developmental Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7884642/
https://ncbi.nlm.nih.gov/pubmed/33604336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.625231
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