Manifestation of Huntington’s disease pathology in human induced pluripotent stem cell-derived neurons

BACKGROUND: Huntington’s disease (HD) is an incurable hereditary neurodegenerative disorder, which manifests itself as a loss of GABAergic medium spiny (GABA MS) neurons in the striatum and caused by an expansion of the CAG repeat in exon 1 of the huntingtin gene. There is no cure for HD, existing p...

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Veröffentlicht in:Mol Neurodegener
Hauptverfasser: Nekrasov, Evgeny D., Vigont, Vladimir A., Klyushnikov, Sergey A., Lebedeva, Olga S., Vassina, Ekaterina M., Bogomazova, Alexandra N., Chestkov, Ilya V., Semashko, Tatiana A., Kiseleva, Elena, Suldina, Lyubov A., Bobrovsky, Pavel A., Zimina, Olga A., Ryazantseva, Maria A., Skopin, Anton Yu., Illarioshkin, Sergey N., Kaznacheyeva, Elena V., Lagarkova, Maria A., Kiselev, Sergey L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832474/
https://ncbi.nlm.nih.gov/pubmed/27080129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0092-5
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