Manifestation of Huntington’s disease pathology in human induced pluripotent stem cell-derived neurons

BACKGROUND: Huntington’s disease (HD) is an incurable hereditary neurodegenerative disorder, which manifests itself as a loss of GABAergic medium spiny (GABA MS) neurons in the striatum and caused by an expansion of the CAG repeat in exon 1 of the huntingtin gene. There is no cure for HD, existing p...

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Dades bibliogràfiques
Publicat a:Mol Neurodegener
Autors principals: Nekrasov, Evgeny D., Vigont, Vladimir A., Klyushnikov, Sergey A., Lebedeva, Olga S., Vassina, Ekaterina M., Bogomazova, Alexandra N., Chestkov, Ilya V., Semashko, Tatiana A., Kiseleva, Elena, Suldina, Lyubov A., Bobrovsky, Pavel A., Zimina, Olga A., Ryazantseva, Maria A., Skopin, Anton Yu., Illarioshkin, Sergey N., Kaznacheyeva, Elena V., Lagarkova, Maria A., Kiselev, Sergey L.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832474/
https://ncbi.nlm.nih.gov/pubmed/27080129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0092-5
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