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Discovery of Dipeptides as Potent Botulinum Neurotoxin A Light-Chain Inhibitors
[Image: see text] The botulinum neurotoxin, the caustic agent that causes botulism, is the most lethal toxin known to man. The neurotoxin composed of a heavy chain (HC) and a light chain (LC) enters neurons and cleaves SNARE proteins, leading to flaccid paralysis, which, in severe occurrences, can r...
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| Veröffentlicht in: | ACS Med Chem Lett |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Chemical Society
2021
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7883461/ https://ncbi.nlm.nih.gov/pubmed/33603978 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00674 |
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