Mitochondria-targeted magnolol inhibits OXPHOS, proliferation, and tumor growth via modulation of energetics and autophagy in melanoma cells

INTRODUCTION: Melanoma is an aggressive form of skin cancer for which there are no effective drugs for prolonged treatment. The existing kinase inhibitor antiglycolytic drugs (B-Raf serine/threonine kinase or BRAF inhibitors) are effective for a short time followed by a rapid onset of drug resistanc...

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Publicat a:Cancer Treat Res Commun
Autors principals: Cheng, Gang, Hardy, Micael, Zielonka, Jacek, Weh, Katherine, Zielonka, Monika, Boyle, Kathleen A., Abu Eid, Mahmoud, McAllister, Donna, Bennett, Brian, Kresty, Laura A., Dwinell, Michael B., Kalyanaraman, Balaraman
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7883397/
https://ncbi.nlm.nih.gov/pubmed/32987287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ctarc.2020.100210
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