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Centriolar distal appendages activate the centrosome‐PIDDosome‐p53 signalling axis via ANKRD26
Centrosome amplification results into genetic instability and predisposes cells to neoplastic transformation. Supernumerary centrosomes trigger p53 stabilization dependent on the PIDDosome (a multiprotein complex composed by PIDD1, RAIDD and Caspase‐2), whose activation results in cleavage of p53’s...
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| Publicado no: | EMBO J |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7883297/ https://ncbi.nlm.nih.gov/pubmed/33350486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020104844 |
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