Centriolar distal appendages activate the centrosome‐PIDDosome‐p53 signalling axis via ANKRD26

Centrosome amplification results into genetic instability and predisposes cells to neoplastic transformation. Supernumerary centrosomes trigger p53 stabilization dependent on the PIDDosome (a multiprotein complex composed by PIDD1, RAIDD and Caspase‐2), whose activation results in cleavage of p53’s...

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Publicat a:EMBO J
Autors principals: Burigotto, Matteo, Mattivi, Alessia, Migliorati, Daniele, Magnani, Giovanni, Valentini, Chiara, Roccuzzo, Michela, Offterdinger, Martin, Pizzato, Massimo, Schmidt, Alexander, Villunger, Andreas, Maffini, Stefano, Fava, Luca L
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7883297/
https://ncbi.nlm.nih.gov/pubmed/33350486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020104844
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