The PIDDosome activates p53 in response to supernumerary centrosomes

Centrosomes, the main microtubule-organizing centers in animal cells, are replicated exactly once during the cell division cycle to form the poles of the mitotic spindle. Supernumerary centrosomes can lead to aberrant cell division and have been causally linked to chromosomal instability and cancer....

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Bibliografiske detaljer
Udgivet i:Genes Dev
Main Authors: Fava, Luca L., Schuler, Fabian, Sladky, Valentina, Haschka, Manuel D., Soratroi, Claudia, Eiterer, Lisa, Demetz, Egon, Weiss, Guenter, Geley, Stephan, Nigg, Erich A., Villunger, Andreas
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5287111/
https://ncbi.nlm.nih.gov/pubmed/28130345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.289728.116
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