Crystal structure of bacterial cytotoxic necrotizing factor CNF(Y) reveals molecular building blocks for intoxication

Cytotoxic necrotizing factors (CNFs) are bacterial single‐chain exotoxins that modulate cytokinetic/oncogenic and inflammatory processes through activation of host cell Rho GTPases. To achieve this, they are secreted, bind surface receptors to induce endocytosis and translocate a catalytic unit into...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Chaoprasid, Paweena, Lukat, Peer, Mühlen, Sabrina, Heidler, Thomas, Gazdag, Emerich‐Mihai, Dong, Shuangshuang, Bi, Wenjie, Rüter, Christian, Kirchenwitz, Marco, Steffen, Anika, Jänsch, Lothar, Stradal, Theresia E B, Dersch, Petra, Blankenfeldt, Wulf
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7883292/
https://ncbi.nlm.nih.gov/pubmed/33410511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020105202
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