The Dysregulated Galectin Network Activates NF-κB to Induce Disease Markers and Matrix Degeneration in 3D Pellet Cultures of Osteoarthritic Chondrocytes

This work aimed to study the dysregulated network of galectins in OA chondrocyte pellets, and to assess whether their recently discovered activity as molecular switches of functional biomarkers results in degradation of extracellular matrix in vitro. Scaffold-free 3D pellet cultures were established...

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Bibliografiske detaljer
Udgivet i:Calcif Tissue Int
Main Authors: Pichler, K. M., Weinmann, D., Schmidt, S., Kubista, B., Lass, R., Martelanz, L., Alphonsus, J., Windhager, R., Gabius, H. -J., Toegel, S.
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2020
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7881967/
https://ncbi.nlm.nih.gov/pubmed/33185768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00223-020-00774-4
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