TLR9 Deficiency in B Cells Promotes Immune Tolerance via Interleukin-10 in a Type 1 Diabetes Mouse Model

Toll-like receptor 9 (TLR9) is highly expressed in B cells, and B cells are important in the pathogenesis of type 1 diabetes (T1D) development. However, the intrinsic effect of TLR9 in B cells on β-cell autoimmunity is not known. To fill this knowledge gap, we generated NOD mice with a B-cell–specif...

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Publicado en:Diabetes
Autores principales: Sha, Sha, Pearson, James A., Peng, Jian, Hu, Youjia, Huang, Juan, Xing, Yanpeng, Zhang, Luyao, Zhu, Ying, Zhao, Hongyu, Wong, F. Susan, Chen, Li, Wen, Li
Formato: Artigo
Lenguaje:Inglês
Publicado: American Diabetes Association 2021
Materias:
Immunology and Transplantation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7881860/
https://ncbi.nlm.nih.gov/pubmed/33154070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db20-0373
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